My work is aimed towards understanding the determinants of substrate selection specificity in biological systems, with a focus on high-fidelity variants of the CRISPR-Cas9 genome editing system. I use various methods, including the backwards chemical master equation formalism, to examine potential mechanisms
of increased substrate selection specificity in Cas9.
![Andrew](/sites/g/files/bxs3881/files/2023-05/2018_Headshot_Andrew_Hecht.png)