My postdoc project focuses on improving the precision of BEs (base editors). BEs can initiate C->T (or G->A)  conversion in a programmable manner. However, it is challenging for the editor to modify only the specific base if identical bases can be found close to the target. The goal of many scientists worldwide remains single-base genome editing at the given site. We use a discrete-state stochastic model to investigate the dynamics of single-base editing. The first-passage method has been utilized to evaluate probabilities of different outcomes and the average times it takes to edit target or bystander.


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