Photo of Yousif Shamoo

WEBSITE(S)| PubMed Publication List | Shamoo Lab

Yousif Shamoo served as Vice Provost for Research from 2014 to 2022, overseeing strategic planning for the university’s research enterprise including engagement with industry through research and technology transfer. He was appointed Professor of BioSciences in 2012, and first joined the Rice University faculty in 1998. He served as Rice’s Director of the Institute of BioSciences and Bioengineering from 2008-2014, leading the coordination of interdisciplinary research among Rice faculty. He received his doctorage in Molecular Biophysics and Biochemistry from Yale University in 1988.

Shamoo’s research lab studies the dangerous rise of multi-drug resistant bacteria. With multi-drug resistant bacteria becoming increasingly common in hospitals, antibiotic resistance has threatened to return us to a pre-antibiotic era that would completely undermine modern medicine. His work seeks to elucidate the underlying biophysical principles of adaptation within bacterial populations during protein evolution. His group uses a combination of experimental evolution and biophysical approaches including X-ray crystallography, enzyme kinetics, protein folding, calorimetry and genomics to link changes in protein structure and function to their resulting phenotypes within evolving populations. His lab extends these physicochemical principles to predict the success or failure of specific adaptive alleles undergoing selection. By combining approaches from biophysics, genomics and experimental evolution, his group is able to identify and characterize successful evolutionary trajectories and then link those intermediates to the overall evolutionary trajectory of the bacterial populations.

Shamoo receives research support from the National Institutes of Health and the Department of Defense. He serves as a member of the National Institutes of Health Genetic Variation and Evolution Study Section, and reviews for the National Science Foundation and Department of Defense. He is the recipient of the American Society for Microbiology Distinguished Lecturer award from 2011-2013 and Rice’s top teaching award, the George R. Brown Award for Excellence in Teaching in 2015. He also received the George R. Brown Award for Superior Teaching four times since 2009. In 2020, he was named as Ralph and Dorothy Looney Professor.

Research Areas

Structural biology, molecular evolution, X-ray crystallography, microbial evolution, antibiotic resistance


1983, Bachelor of Science in Biology, Carnegie-Mellon University

1988, Doctorate in Molecular Biophysics and Biochemistry, Yale University

Honors & Awards

American 2011-2013, Society for Microbiology Distinguished Lecturer award

2015, George R. Brown Award for Excellence in Teaching

2009, plus three subsequent years, George R. Brown Award for Superior Teaching

2020, named Ralph and Dorothy Looney Professor


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