Joel Moake

WEBSITE(S)| Moake Laboratory in Hematological Research

Dr. Joel Moake specializes in fundamental studies of platelet function. His group was the first to describe basic mechanisms of platelet adhesion and aggregation under high shear stress; systemic platelet aggregation in the most extreme platelet clumping disorder, thrombotic thrombocytopenic purpura (TTP); and renal platelet thrombosis in a common cause of acute kidney failure, the hemolytic-uremic syndrome (HUS).

Dr. Moake’s Laboratory in Hematological Research focus on the molecular events associated with TTP and HUS —especially, the interaction between the adhesive multimeric protein, von Willebrand factor (VWF), and the VWF-cleaving metalloprotease enzyme, ADAMTS-13. His long-term goal is to translate basic research observations obtained in the study of these severe, paradigm platelet clumping disorders into the development of novel therapeutic strategies for the treatment of common, localized thrombotic processes that are characteristic of heart attacks and strokes.

In recognition of his research accomplishments, Dr. Moake is an elected member of the American Society for Clinical Investigation, an elected member of the Association of American Physicians, a fellow of the American Institute for Medical and Biological Engineering, and a fellow of the American College of Physicians. He is also a founding member of Rice University’s Department of Bioengineering undergraduate and graduate programs.

Recent invited lectures where Dr. Moake has presented his lab’s findings include: the 2015 Brodsky Lecture in Hematology, Johns Hopkins U. School of Medicine/ Hospital, and the 2014 Emory U. School of Medicine/Georgia Inst. of Technology/Aflac Cancer & Blood Disorders Center.

Research Areas

For over 25 years, the Moake Laboratory in Hemostasis-Thrombosis Research has investigated the basic mechanisms of hemostasis-thrombosis under flowing conditions, and the pathophysiology of thrombotic microangiopathies. More specifically this has included: Shear stress-induced, von Willebrand factor (VWF)-mediated platelet clumping; Pathophysiology and therapy of thrombotic thrombocytopenic purpura (TTP), and hemolytic-uremic syndromes HUS), and other types of thrombotic microangiopathies; Molecular interactions between VWF and complement; and production and activation of coagulation proteins on human endothelial cells.

Education

M.D., Johns Hopkins University School of Medicine (1967)

B.A., Johns Hopkins University (1964)

Societies & Organizations

Member, American Society of Clinical Investigation

Member, Association of American Physicians

Fellow, American Institute for Medical and Biological Engineering

Fellow, American College of Physicians

Founding Member, Rice University Department of Bioengineering

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