Christopher Sperandio's collaborative art work explores the numerous margins between mass and museum cultures. Sperandio's work takes the form of comic books, television, painted installation, and web sites.
 
Sperandio has had two solo shows at American Fine Arts, a landmark New York art gallery. He has produced new collaborative projects for museums and art centers in the US, Germany, Northern Ireland, Denmark, England Scotland, Wales, Spain, and France, and with institutions such as MoMA/PS1, London's Institute of Contemporary Art, Fantagraphics Books and DC Comics. Sperandio is also the Creator and Executive Producer of ARTSTAR, a reality television series based in the New York art world, airing internationally and in the US on GalleryHD, part of the VOOM Network.
 
He has been written about widely. His work appears in numerous survey books especially concerning relational, interactive and collaborative art. Chapter ten of Arthur Danto's book After the End of Art is dedicated mainly to Sperandio's collaborative project "We Got it!" Sperandio's works have also been written about in the New York Times, Art In America, Artforum, Frieze, Flash Art, Sculpture Magazine, The New Yorker, ArtReview, Art Papers, Soap Opera Weekly and others.
 
Sperandio has lectured about his own work, comic books and television at museums, universities, conferences, and symposia in the US, Poland, Germany, England, Scotland and Wales. He has given presentations at the International Sculpture Conference, and the College Art Association. From 2000 to 2004 he was a contributing artist at Wired Magazine, drawing the cover of the May 2001 issue. Educational institution affiliations include Princeton, School of the Museum of Fine Arts, Boston, Carnegie Mellon University, The School of the Art Institute of Chicago and Virginia Commonwealth University. Sperandio is a founding member of Kartoon Kings, a media company engaged in the production of comic books, animations and films. Kartoon Kings is dedicated to the production and creation of works of art and to the extension of art across audiences and media boundaries. Kartoon Kings is in partnership with Sperandio's long-time collaborative partner, Simon Grennan.