Antonios Mikos

WEBSITE(S)| Mikos Research Group | Center for Engineering Complex Tissues | Center for Excellence in Tissue Engineering | Google Scholar Profile

Antonios G. Mikos is the Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering at Rice University. He is the Director of the National Institutes of Health Center for Engineering Complex Tissues, the Director of the Center for Excellence in Tissue Engineering, and the Director of the J.W. Cox Laboratory for Biomedical Engineering at Rice University. He received his Dipl.Eng. (1983) from the Aristotle University of Thessaloniki, Greece, and his Ph.D. (1988) in chemical engineering from Purdue University. He was a postdoctoral researcher at the Massachusetts Institute of Technology and the Harvard Medical School before joining the Rice Faculty in 1992 as an assistant professor.

Mikos’ research focuses on the synthesis, processing, and evaluation of new biomaterials for use as scaffolds for tissue engineering, as carriers for controlled drug delivery, as non-viral vectors for gene therapy, and as platforms for disease modeling. His work has led to the development of novel orthopaedic, dental, cardiovascular, neurologic, and ophthalmologic biomaterials. He is the author of over 640 publications and 32 patents. He is the editor of 15 books and the author of one textbook (Biomaterials: The Intersection of Biology and Materials Science, Pearson Prentice Hall, 2008). Mikos is among the top 1 percent most cited researchers in his field. He has been cited over 83,000 times and has an h-index of 150.

Mikos is a Member of the National Academy of Engineering, a Member of the National Academy of Medicine, a Member of the International Academy of Medical and Biological Engineering, a Member of the Academia Europaea, a Member of the Academy of Medicine, Engineering and Science of Texas, and a Member of the Academy of Athens. He is a Founding Fellow of the Tissue Engineering and Regenerative Medicine International Society, a Fellow of the American Association for the Advancement of Science, a Fellow of the American Institute of Chemical Engineers, a Fellow of the American Institute for Medical and Biological Engineering, a Fellow of the Biomedical Engineering Society, a Fellow of the Controlled Release Society, a Fellow of the International Union of Societies for Biomaterials Science and Engineering, and a Fellow of the National Academy of Inventors.

Mikos has been recognized by various awards including the Lifetime Achievement Award of the Tissue Engineering and Regenerative Medicine International Society-Americas, the Founders Award and the Clemson Award for Contributions to the Literature of the Society For Biomaterials, the Founders Award of the Controlled Release Society, the Robert A. Pritzker Distinguished Lecturer Award and the Shu Chien Achievement Award of the Biomedical Engineering Society, the Acta Biomaterialia Gold Medal, the Excellence in Surface Science Award of the Surfaces in Biomaterials Foundation, the Alpha Chi Sigma Award for Chemical Engineering Research and the James E. Bailey Award in Biological Engineering of the American Institute of Chemical Engineers, the Meriam/Wiley Distinguished Author Award of the American Society for Engineering Education, the Edith and Peter O’Donnell Award in Engineering of the Academy of Medicine, Engineering and Science of Texas, the Marshall R. Urist Award for Excellence in Tissue Regeneration Research of the Orthopaedic Research Society, the Distinguished Scientist Award – Isaac Schour Memorial Award of the International Association for Dental Research, and the Distinguished Engineering Alumnus Award of Purdue University.

Mikos has mentored 69 graduate students on their way to completing their doctoral studies, as well as 40 postdoctoral fellows, 22 of whom remain in academia at institutions including Chung-Ang University, Dongguk University, Georgia Tech, Hanyang University, Mayo Clinic, National University of Singapore, Tulane University, University of Maryland, University of New Mexico, University of Oklahoma, University of Texas at Austin, University of Texas Health Science Center at Houston, University of Texas Rio Grande Valley, and Virginia Tech among others. He has given over 780 presentations in national and international meetings and over 210 invited seminars at universities and companies. He is organizer of the continuing education course Advances in Tissue Engineering offered annually at Rice University since 1993.

Mikos is a founding editor and editor-in-chief of the journals Tissue Engineering Part A, Tissue Engineering Part B: Reviews, and Tissue Engineering Part C: Methods and a member of the editorial boards of the journals Advanced Drug Delivery Reviews, Cell Transplantation, Journal of Biomaterials Science Polymer Edition, Journal of Biomedical Materials Research (Part A and B), and Journal of Controlled Release. He is Past-President of the Tissue Engineering and Regenerative Medicine International Society-Americas and the Society For Biomaterials.


Research Statement

Ongoing projects in the Mikos Research Group include:

• Investigating novel 3D printing and bioprinting strategies for manufacturing biodegradable polymer scaffolds with precise geometries, physiologically relevant tissue architecture, and controlled release of biochemical signals to direct stem cell differentiation and tissue formation for bone and cartilage regeneration and repair;
• Synthesizing novel extracellular matrix-derived and nanomaterial-based bioinks for 3D printing;
• Fabricating injectable, in situ polymerizable, biodegradable composite scaffolds as carriers for stem cells for osteochondral tissue engineering;
• Harnessing biomimetic strategies to promote articular cartilage regeneration;
• Designing tunable and electro-active scaffolds of decellularized extracellular matrix for skeletal muscle repair;
• Leveraging mechanically tunable polymeric scaffolds and in vitro bioreactors to examine the effects of mechanical forces and various cellular compartments within the tumor microenvironment on disease progression and drug resistance profiles of bone sarcomas; and
• Developing in vivo bioreactors for craniofacial reconstruction.

Research Areas

Biomaterials, Drug Delivery, Tissue Engineering.

Education

Postdoctoral Fellow, MIT, Harvard Medical School (1990-1991)

Ph.D., Chemical Engineering, Purdue University (1988)

M.S.Ch.E., Chemical Engineering, Purdue University (1985)

Dipl.Ch.E., Chemical Engineering, Aristotle University of Thessaloniki, Greece (1983)

Societies & Organizations

Member, National Academy of Engineering

Member, National Academy of Medicine

Member, International Academy of Medical and Biological Engineering

Member, Academia Europaea

Member, Academy of Medicine, Engineering and Science of Texas

Member, Academy of Athens

Founding Fellow, Tissue Engineering and Regenerative Medicine International Society

Fellow, American Association for the Advancement of Science

Fellow, American Institute of Chemical Engineers

Fellow, American Institute for Medical and Biological Engineering

Fellow, Biomedical Engineering Society

Fellow, Controlled Release Society

Fellow, International Union of Societies for Biomaterials Science and Engineering

Fellow, National Academy of Inventors

Honors & Awards

Lifetime Achievement Award, Tissue Engineering and Regenerative Medicine International Society-Americas

Founders Award and Clemson Award for Contributions to the Literature, Society of Biomaterials

Founders Award, Controlled Release Society

Robert A. Pritzker Distinguished Lecturer Award, Biomedical Engineering Society (BMES)

Gold Medal, Acta Biomaterialia

Excellence in Surface Science Award, Surfaces in Biomaterials Foundation

Alpha Chi Sigma Award for Chemical Engineering Research and James E. Bailey Award in Biological Engineering, American Institute of Chemical Engineers

Meriam/Wiley Distinguished Author Award, American Society for Engineering Education

Edith and Peter O’Donnell Award in Engineering, Academy of Medicine, Engineering and Science of Texas (TAMEST)

Marshall R. Urist Award for Excellence in Tissue Regeneration Research, Orthopaedic Research Society

Distinguished Scientist Award – Isaac Schour Memorial Award, International Association for Dental Research

Distinguished Engineering Alumnus Award, Purdue University